The latest scientific, medical and healthcare advances in Applied Mastology and Breast Cancer Treatment, compiled in a comprehensive, high-performance Postgraduate diploma”

This Postgraduate diploma seeks to make the student aware of the current importance of Diagnostics.The paradigm is that diagnostic effort saves therapeutic effort, but so is the need to use diagnostic tools to individualize the pathological process, especially the tumor, which allows individualization of treatment, the so-called Tailord Therapy, the central pillar of precision medicine (and oncology).

This precision oncology aims to maximize the use of available and effective drugs, reducing the dangers of over- and under-treatment, which are responsible for a significant percentage of global mortality.

The achievement of this objective will require preparing the student in the rational, protocolized and efficient use of diagnostic resources, including sophisticated diagnostic tools for both imaging and biopsy or deep genetic knowledge of the somatic and germline branches. But it will not neglect ancestral procedures, in many cases, with an added therapeutic effect, by generating confidence, proximity and security in the patient. We refer to the arts of Anamnesis and Semiology and even of the Philosophy that guides our diagnostic action through the channel of such wise thoughts as the Hippocratic, which encourages us to deal, not with diseases, but with sick people, with man and on this occasion, especially, the sick woman, always taking into consideration its totality, physical, psychological and spiritual.

Structural knowledge of breast disease is the cornerstone of what we now call individual patient-based medicine and, in neoplastic disease, Precision Oncology. Already since the end of the 20th century, we knew about the diversity of breast cancer genotypes and suspected (empirically) the therapeutic specificity of each one. Fundamentally, we knew the effectiveness of estrogen blockade in Luminal Genotype.

The development and clinical use of Trastuzumab by Genentech, to block the Her2 receptor pathway, meant, in the words of cancer historian S Mukherjee, something as if in cholera, we had gone from treating diarrhea to fighting the parasite. Certainly, there would be a field of targeted therapy, which needed a thorough knowledge of the molecular structure of Cancer and Human.

Improve the quality of care for your patients with this highly scientifically rigorous specialization"

This Postgraduate diploma in Diagnostics in Mastology contains the most complete and up-to-date scientific program on the market. The most important features of the program include:

• Graphic, schematic, and highly practical contents
• The latest developments and cutting-edge advances in this area
• Practical exercises where the self-evaluation process can be carried out to improve learning
• Innovative and highly efficient methodologies
• Theoretical lessons, questions to the expert, debate forums on controversial topics, and individual reflection assignments
• Content that is accessible from any fixed or portable device with an Internet connection

The latest advances in the area of Applied Mastology and Breast Cancer Treatment compiled in a highly efficient preparative Postgraduate diploma, which will optimize your effort with the best results”

The development of this Postgraduate diploma is focused on the practice of the proposed theoretical learning. Through the most effective teaching systems, proven methods imported from the most prestigious universities in the world, you will be able to acquire new knowledge in a practical way. In this way, we strive to convert your efforts into real and immediate skills.

Our online system is another of the strengths of our training course. With an interactive platform that has the advantages of the latest technological developments, we put the most interactive digital tools at your service. In this way we can offer you a totally adaptable way of learning for your own specific needs, so you can combine this specialization perfectly with your personal and professional life.

A unique Postgraduate diploma that perfectly combines preparatory intensity, with the most innovative knowledge and techniques of the sector, with the flexibility that the working professional needs"

A program designed to allow you to implement the knowledge that you acquire almost immediately in your daily practice"

The structure of the contents has been designed by a team of professionals, aware of the relevance of current specialization in order to advance in the labor market with security and competitiveness, and to practice your profession with the excellence that only the best training allows.

This Innovative Postgraduate diploma in Diagnostics in Mastology contains the most complete and up-to-date scientific program on the market”

Module 1. Diagnostics in Mastology

1.1. Introduction to Imaging Diagnostics in Mastology
1.2. Radiological Interpretation in Breast Pathology
1.3. Nodule and Asymmetric Breasts
1.4. Diagnostic Management of Microcalcifications and Distortion of the Breast Architecture
1.5. Mammary Interventionism
1.6. Pre-Treatment Clinical Staging in Breast Cancer
1.7. Other Indications of Mammary Magnetic Resonance
1.8. Treated and Operated Breast
1.9. Uncommon Breast Pathology, Special Situations
1.10. Advances in Mammary Diagnostics and Interventionism

Module 2. Pathologic Anatomy/Pathogenesis

2.1. Introduction to Breast Pathological Anatomy

2.1.1. Concepts. Anatomopathological Language  
2.1.2. Methods for Studying Pathological Anatomy  
2.1.3. Types of Samples
2.1.4. Clinical and Radiological Correlation

2.1.4.1. Surgical Specimen Orientation  

2.1.5. Diagnostics: The Anatomopathological Report 
2.1.6. Normal Breast

2.2. Benign Epithelial Tumors Papillary Neoplasms Premalignant Lesions

2.2.1. Benign Epithelial Proliferations and Precursors

2.2.1.1. Usual Ductal Hyperplasia
2.2.1.2. Columnar Cell Lesions, Including Flat Epithelial Atypia
2.2.1.3. Atypical Ductal Hyperplasia

2.2.2.    Adenosis and Benign Sclerosing Lesions

2.2.2.1. Sclerosing Adenosis 
2.2.2.2. Adenosis and Apocrine Adenoma
2.2.2.3. Adenosis Microglandular
2.2.2.4. Radial Scar and Complex Sclerosing Lesion

2.2.3.    Adenomas

2.2.3.1. Tubular Adenoma 
2.2.3.2. Lactational Adenoma 
2.2.3.3. Ductal Adenoma

2.2.4. Epithelial-Myoepithelial Tumors

2.2.4.1. Pleomorphic Adenoma 
2.2.4.2. Adenomyoepithelioma

2.2.5. Papillary Neoplasms

2.2.5.1. Intraductal Papilloma 
2.2.5.2. Papillary Ductal Carcinoma in situ
2.2.5.3. Encapsulated Papillary Carcinoma
2.2.5.4. Solid Papillary Carcinoma in situ

2.2.6. Non-Invasive Lobular Neoplasia

2.2.6.1. Atypical lobular hyperplasia 
2.2.6.2. Lobular Carcinoma in situ

2.2.7.    Ductal Carcinoma in situ

2.3. Malignant Epithelial Tumors

2.3.1. Infiltrating Carcinoma and Subtypes

2.3.1.1. Infiltrating Carcinoma Without a Special Subtype
2.3.1.2. Microinfiltrating Carcinoma 
2.3.1.3. Infiltrating Lobular Carcinoma
2.3.1.4. Tubular Carcinoma 
2.3.1.5. Cribriform Carcinoma 
2.3.1.6. Mucinous Carcinoma 
2.3.1.7. Mucinous Cystadenocarcinoma 
2.3.1.8. Infiltrating Micropapillary Carcinoma
2.3.1.9. Infiltrating Solid Papillary Carcinoma 
2.3.1.10. Infiltrating Papillary Carcinoma 
2.3.1.11. Carcinoma with Apocrine Differentiation
2.3.1.12. Metaplastic Carcinoma

2.3.2.    Saliva Gland Type Carcinomas

2.3.2.1. Acinar Cell Carcinoma
2.3.2.2. Adenoid Cystic Carcinoma
2.3.2.3. Secretor Carcinoma
2.3.2.4. Mucoepidermoid Carcinoma 
2.3.2.5. Polymorphous Adenocarcinoma 
2.2.2.6. Tall Cell Carcinoma with Reverse Polarization

2.3.3. Neuroendocrine Neoplasms

2.3.3.1. Neuroendocrine Tumor  
2.3.3.2. Neuroendocrine Carcinoma

2.4. Fibroepithelial Tumors Nipple-areola complex Tumors Hematolymphoid Tumors

2.4.1. Fibroepithelial Tumors
2.4.1.1. Hamartoma 
2.4.1.2. Fibroadenoma
2.4.1.3. Tumor Phyllodes

2.4.2.    Nipple-areola Complex Tumors

2.4.2.1. Syringomatous Tumor
2.4.2.2. Nipple Adenoma
2.4.2.3. Paget’s Disease of the Breast

2.4.3.    Hematolymphoid Tumors

2.4.3.1. MALT Lymphoma
2.4.3.2. Follicular Lymphoma
2.4.3.3. Diffuse Large B-cell Lymphoma
2.4.3.4. Burkitt's lymphoma
2.4.3.5. Anaplastic Large Cell Lymphoma Associated with Breast Implantation

2.5. Mesenchymal Tumors

2.5.1. Vascular Tumors

2.5.1.1. Hemangioma 
2.5.1.2. Angiomatosis 
2.5.1.3. Atypical Vascular Lesions
2.5.1.4. Primary Angiosarcoma 
2.5.1.5. Post-Radiation Angiosarcoma

2.5.2.    Fibroblastic and Myofibroblastic Tumors

2.5.2.1. Nodular Fascitis 
2.5.2.2. Myofibroblastoma 
2.5.2.3. Desmoid Fibromatosis 
2.5.2.4. Inflammatory Myofibroblastic Tumor

2.5.3.    Peripheral Nerve Sheath Tumors

2.5.3.1. Schwanoma 
2.5.3.2. Neurofibroma 
2.5.3.3. Granular Cells Tumor

2.5.4.    Smooth Muscle Tumors

2.5.4.1. Leiomyoma 
2.5.4.2. Leiomyosarcoma

2.5.5.    Adipocytic Tumors

2.5.5.1. Lipoma 
2.5.5.2. Angiolipoma 
2.5.5.3. Liposarcomas

2.6. Clinical Pathological Special Situations Genetic Tumor Syndromes

2.6.1. Clinical Pathological Special Situations

2.6.1.1. Young Woman
2.6.1.2. Pregnancy and Lactation
2.6.1.3. Elderly Woman
2.6.1.4. Men
2.6.1.5. Hidden
2.6.1.6. Inflammatory Carcinoma

2.6.2. Genetic Tumor Syndromes

2.6.2.1. BRCA1/2-Associated Hereditary Breast and Ovarian Cancer Syndrome
2.6.2.2. Cowden Syndrome
2.6.2.3. Ataxia-Telangiectasia
2.6.2.4. TP53-Associated Li-Fraumeni Syndrome
2.6.2.5. CHEK2-Associated Li-Fraumeni Syndrome
2.6.2.6. CDH1-Associated Breast Cancer 
2.6.2.7. Cancer Associated with PALB2
2.6.2.8. Peutz-Jeghers Syndrome
2.6.2.9. Neurofibromatosis Type I

2.7. Non-Tumorous Pathology

2.7.1. Pseudoangiomatous Stromal Hyperplasia
2.7.2. Diabetic Mastopathy 
2.7.3. Fibrosis
2.7.4. Mondor Disease 
2.7.5. Changes Due to Breastfeeding
2.7.6. Mastitis

2.7.6.1. Mastitis Granulomatosa 
2.7.6.2. Mastitis Non-Granulomatosa

2.8. Prognosis

2.8.1. Tumor Grade 
2.8.2. Pathological Staging  
2.8.3. Surgical Border 
2.8.4. Sentinel Lymph Node

2.8.4.1. OSNA

2.8.5. Treatment-Oriented Immunohistochemistry Classes  
2.8.6. Nomograms  

2.8.6.1. Cases

2.9. Prediction

2.9.1.Evaluation of Response to Neoadjuvant Treatment 
2.9.2.Prediction of the Response to Chemotherapy Treatment  

2.9.2.1. Genetic Platforms Oncotye DX, Mamaprint, PAM50 

2.9.3. Therapeutic Targets 
2.9.4.NGS 
2.9.5.Digital and Computational Pathology

2.9.5.1. Cases

2.10. Multimodality

2. 10.1.Positive, Negative or Uncertain  
2.10.2. Interpretation of Data in the Clinical Context  

2.10.2.1. Statistics and Probability 

2.10.3.    Quality Control  

2.10.3.1. Protocols

2.10.4.    Pathologists in the Breast Unit

2.10.4.1. Difficult Cases: are tumors, occult primary, non-breast OSNA, very long monitoring processes

2.10.5.    Conclusions

Module 3. Functional Anatomy

3.1. Radiological Anatomy of the Mammary Region
3.2. Radiological Anatomy of the Donor Regions in Reconstructive Breast Surgery
3.3. Surgical Anatomy in Oncology Surgery and Reconstructive Topography, Anatomical Relations 
3.4. Muscular Surroundings
3.5. Arterial and Venous Vascularization

3.5.1. Key Points of Vascularization in the Conservation of Skin and Areola
3.5.1. Key Points of Vascularization in the Muscular Preservation and Local Flaps

3.6. Lymphatic Drainage
3.7. Innervation
3.8. Axillary Cavity

3.8.1. Limits
3.8.2. Vascular Content
3.8.3. Nerve Content
3.8.4. Ganglionic Content, Berg Levels. Surgical Approaches to the Axilla

3.9. Internal Mammary Role in Free Flaps
3.10. Supraclavicular Region

Module 4. Embriology, Malformations, Intersexual States

4.1. Embryology 
4.2. Physiology
4.3. Mammary malformations

4.3.1. Polymastia
4.3.2. Muscle Abnormalities and Agenesis Poland Syndrome
4.3.3. Tubular Breasts
4.3.4. Alterations of the Nipple-areola Complex

4.4. Macromastia and Micromastia
4.5. Gynecomastia
4.6. Intersexual Syndromes
4.7. Breast Cancer in Childhood and Adolescence:

4.7.1. Environmental Causes
4.7.2. Genetic Causes

4.8. Inflammatory Disease

4.8.1. Acute Mastitis Abscess
4.8.2. Chronic Mastitis
4.8.3. Mondor Disease
4.8.4. Plasmatic Cell Mastitis
4.8.5. Periductal Mastitis

4.9. Systemic

4.9.1. Sarcoidosis
4.9.2. Granulomatosis

4.10. Burns in the Mammary Area in Childhood and Adolescence

A unique, key and decisive training experience to boost your professional development"