The latest scientific, medical and healthcare advances in Applied Mastology and Breast Cancer Treatment, compiled in a comprehensive, high-performance Postgraduate diploma”

To establish an indication for conservative surgery, we need to establish a complete diagnosis of nodularity, phenotype clonality, in situ component, histologic grade and relative risk of the remaining and contralateral breast.

Once the indication is established, an adequate oncoplastic knowledge will allow oncologic resection and plastic remodeling, using therapeutic mammoplasty, partial reconstruction or glandulectomy and immediate reconstruction with biological matrices or de-epithelialized flaps. 

Only the knowledge of these circumstances and procedures, which we intend to describe in this chapter, allows us to face the challenge.

The axilla is the fundamental staging area, but also the site of undesirable immunologic changes during tumor progression and also the closest station of cellular immunity in a healthy state. 

If we add to this its role in the lymphatic drainage of the breast and arm and the seat of vasculonervous structures essential for the good function of the arm and thoracic wall as well as for the viability of possible flaps, we will understand the importance of knowledge of the surgical anatomy, the surgical management before and after neoadjuvant surgery and its lymphatic mapping.

Another specialty particularly linked to breast surgery is nuclear medicine with a priceps role in axillary management and radiolocalization of occult lesions.

The goal of systemic therapy remains to reduce locoregional disease to allow complete resection or resection-sterilization of locoregional disease but, above all, to eliminate every last residual, cantoned or circulating cell.

Improve the quality of care for your patients with this highly scientifically rigorous specialization"

This Postgraduate diploma in Treatment in Mastology contains the most complete and up-to-date scientific program on the market. The most important features of the program include:

• Graphic, schematic, and highly practical contents
• The latest developments and cutting-edge advances in this area
• Practical exercises where the self-evaluation process can be carried out to improve learning
• Innovative and highly efficient methodologies
• Theoretical lessons, questions to the expert, debate forums on controversial topics, and individual reflection assignments
• Content that is accessible from any fixed or portable device with an Internet connection

The latest advances in the area of Applied Mastology and Breast Cancer Treatment compiled in a highly efficient preparative Postgraduate diploma, which will optimize your effort with the best results”

The development of this Postgraduate diploma is focused on the practice of the proposed theoretical learning. Through the most effective teaching systems, proven methods imported from the most prestigious universities in the world, you will be able to acquire new knowledge in a practical way. In this way, we strive to convert your efforts into real and immediate skills.

Our online system is another of the strengths of our proposal. With an interactive platform that has the advantages of the latest technological developments, we put the most interactive digital tools at your service. In this way we can offer you a totally adaptable way of learning for your own specific needs, so you can combine this specialization perfectly with your personal and professional life.

A unique Postgraduate diploma that perfectly combines preparatory intensity, with the most innovative knowledge and techniques of the sector, with the flexibility that the working professional needs"

A program designed to allow you to implement the knowledge that you acquire almost immediately in your daily practice"

The structure of the contents has been designed by a team of professionals, aware of the relevance of current specialization in order to advance in the labor market with security and competitiveness, and to practice your profession with the excellence that only the best training allows.

This Innovative Postgraduate diploma in Treatment in Mastology contains the most complete and up-to-date scientific program on the market”

Module 1. Locoregional Surgical Treatment in Malignant Breast Pathology

1.1. Role of Locoregional Treatment within a Patient-Based Multimodal Effort

1.1.1. Pre-Therapeutic Diagnostic Evaluation and Strategy
1.1.2. Importance of Neadyuvancy
1.1.3. Importance of Inflammation: Healing Reaction
1.1.4. R0 Resection, Residual Disease and Therapeutic Consolidation Surgical
1.1.5. Pre and Perioperative Care

    1.1.5.1. Antibiotic Prophylaxis
    1.1.5.2. Thromboembolic Prophylaxis
    1.1.5.3. MRSA Screening
    1.1.5.4. Position in the Operating Room
    1.1.5.5. Locoregional Analgesia
    1.1.5.6. Nursing Care

1.1.6. Types of Surgical Procedure in Breast Cancer Selection Criteria

1.2. Breast Conservative Surgery: Basics and Tumorectomy

1.2.1. Indications
1.2.2. Oncologic Principles
1.2.3. Plastic Principles
1.2.4. Guided Surgery

    1.2.4.1. Wire
    1.2.4.2. Markers 
    1.2.4.3. Isotopic (ROLL)
    1.2.4.4. Seeds

1.2.5. Tumorectomy

    1.2.5.1. Lymph Node Involvement
    1.2.5.2. Incisions
    1.2.5.3. Drainages

1.3. Breast Conservative Surgery: Oncoplastic Surgery

1.3.1. Foundations, Pioneers and History
1.3.2. Oncoplastic Procedures Quadrant by Quadrant
1.3.3. Oncoplastic Procedures Divided into Central Breast, Mid Breast; Social Breast and Peripheral Breast
1.3.4. Tubular Breasts and Breast Cancer

1.4. Reduction Mamoplasties and Breast Cancer

1.4.1. Indications
1.4.2. Types

1.5. Reduction Mammoplasties Quadrant by Quadrant

1.5.1. Contralateral Breast Symmetrization Mammoplasty

1.6. Mastectomy

1.6.1. Modified Radical Mastectomy Current Status

    1.6.1.1. Description of the Modified Radical Mastectomy in the Current Day: Indications and Alternatives
    1.6.1.2. Other Radical Mastectomies

1.6.2. Skin and CAP Conservative Mastectomy
1.6.3. Skin-Sparing Mastectomy
1.6.4. Reconstructive Aspects of Conservative Mastectomies

    1.6.4.1. Prosthesis, Meshes and Matrices
    1.6.4.2. Autologous Tissues
    1.6.4.3. Immediate Reconstruction - Deferred

1.7. Stage IV Surgery, Recurrence and Metastases

1.7.1. When and How to Operate on a Metstatic Breast Cancer
1.7.2. Role of Surgery in Locoregional Recurrence, Within a Multidisciplinary Effort
1.7.3. Role of Surgery in Locoregional Palliation Within a Multidisciplinary Effort
1.7.4. Surgery in Locally Advanced Cancer
1.7.5. Electrochemotherapy

1.8. Lymphatic Surgery in Breast Cancer Significance and Importance

1.8.1. Importance of Preoperative Axillary Diagnosis and Marking

1.9. Selective Sentinel Node Biopsy
1.10. Surgical Management of the Axilla Postneadjuvancy

Module 2. Systemic Therapy in Breast Cancer

2.1. Cellular Cycle, Oncogenesis and Pharmacogenomics in Breast Cancer 
2.2. Pharmokinetics and Tumor Response
2.3. Hormone Therapy

2.3.1. Basics of Hormone Therapy
2.3.2. Drugs Used

    2.3.2.1. Selective Estrogen Receptor Modulators
    2.3.2.2. GnRH Analogs
    2.3.2.3. Aromatase Inhibitors
    2.3.2.4. Antiestrogens
    2.3.2.5. Antiprogestorens
    2.3.2.6. Antiandrógenos

2.3.3. Prophylactic

    2.3.3.1. Indications
    2.3.3.2. Drugs Used

        2.3.3.2.1. Tamoxifen
        2.3.3.2.2. Raloxifen
        2.3.3.2.3. Others.

            2.3.3.2.3.1. Retinoids
            2.3.3.2.3.2. Cycloxygenase Inhibitors
            2.3.3.2.3.3. Phytoestrogens
            2.3.3.2.3.4. Statins
            2.3.3.2.3.5. Tibolone
            2.3.3.2.3.6. LHRH Analogs
            2.3.3.2.3.7. Bisphosphonates
            2.3.3.2.3.8. Calcium
            2.3.3.2.3.9. Selenium
            2.3.3.2.3.10. Vitamin D and E
            2.3.3.2.3.11. Lapatinib
            2.3.3.2.3.12. Metformina

2.3.4. Adjuvant

    2.3.4.1. Indications
    2.3.4.2. Duration.
    2.3.4.3. Early Disease

        2.3.4.3.1. Tamoxifen
        2.3.4.3.2. Aromatase Inhibitors
        2.3.4.3.3. LHRH Analogs

    2.3.4.4. Advanced Disease

        2.3.4.4.1. Tamoxifen
        2.3.4.4.2. Aromatase Inhibitors
        2.3.4.4.3. LHRH Analogs and Surgical Castration
        2.3.4.4.4. Cyclin 4-6 Inhibitors

2.3.5. Neoadjuvant.

    2.3.5.1. Indications
    2.3.5.2. Schemes
    2.3.5.3. Duration

2.4. Chemotherapy General Concepts

2.4.1. Basics of Chemotherapy

    2.4.1.1. Importance of Dosis
    2.4.1.2. Resistance to Chemotherapy

2.4.2. Drugs Used

2.5. First Line

2.5.1. Anthracyclines
2.5.2. Taxanes
2.5.3. Paclitaxel
2.5.4. Nab-Paclitaxel
2.5.5. Docetaxel
2.5.6. Others

    2.5.6.1. Other Lines

2.6. Adjuvant

2.6.1. Early Disease

    2.6.1.1. Schemes

2.6.2. Advanced Disease

    2.6.2.1. Indications
    2.6.2.2. Schemes

2.6.3. Neoadjuvant.

    2.6.3.1. Indications and Schemes

2.7. Target Therapies

2.7.1. Drugs Used

    2.7.1.1. Anti Her2
    2.7.1.2. Anti Angiogenics
    2.7.1.3. mTor Inhibitors
    2.7.1.4. Cyclin Inhibitor
    2.7.1.5. Tyrosine Kinase Inhibitor

2.7.2. Adjuvant

    2.7.2.1. Indications
    2.7.2.2. Schemes

2.7.3. Neoadjuvant.

    2.7.3.1. Indications
    2.7.3.2. Schemes

2.8. Immunotherapy
2.9. Support Therapies

2.9.1. Colony Stimulators
2.9.2. Antiemetics
2.9.3. Heart Protectors
2.9.4. Anti-alopecia

2.10. Complications

2.10.1. Infection in the Neutropenic Patient
2.10.2. Fungal and Viral Infections in Patients During Chemotherapy
2.10.3. Endocrine and Metabolic Complications in Patients During Chemotherapy
2.10.4. Emergency Oncology

Module 3. Radiotherapy

3.1. Basis of Radiotherapy

3.1.1. Radiobiology
3.1.2. Immunotherapy

3.2. Indications of Radiotherapy Treatment in the Breast

3.2.1. Radiotherapy after Conservative Treatment
3.2.2. Radiotherapy after Mastectomy
3.2.3. Radiation Therapy After Neoadjuvant Chemotherapy
3.2.4. Radiotherapy on Ganglionic Chains

3.3. Fractionation in Breast Cancer

3.3.1. Normofractionation
3.3.2. Hypofractionation

3.4. New Techniques

3.4.1. Partial Breast Irradiation: IORT, SBRT, External Beam Radiation Therapy

3.5. Radiotherapy in E IV patients: Oligometastatic Disease Palliative Radiotherapy
3.6. Reirradiation in Breast Cancer Radioprophylaxis Radiation Induced Breast Neoplasms
3.7. Radiotherapy and Quality of Life

3.7.1. Toxicity
3.7.2. Life Habits During Radiotherapy Treatment

3.8. Surgery Coordinated with Radiotherapy: Advantages