Specialize in the diagnosis and treatment of this type of tumors and reduce the number of deaths from this cause with the help of the best experts" 

The concept of cancer of unknown origin encompasses a wide range of situations. In general, it refers to tumors that are diagnosed at a metastatic stage, in which, after a correct diagnostic process, we cannot elucidate the origin of the primary tumor. They represent 3-5% of all tumors diagnosed and are the tenth most common type of tumor in developed countries. 

For adults, a cancer is considered rare when its annual incidence is less than 6 cases per 100,000 people. It is estimated that they account for up to 24% of cancers diagnosed in the European Union and about 20% of cancers diagnosed in the United States. 

It must be taken into account that this is an area of great research. Therefore, the evolution of molecular diagnostic techniques has made it possible to detect new genomic alterations, which are likely to cause a tumor phenotype, as well as to have greater precision in the detection of those already known. Currently, the diagnostic accuracy achieved with next-generation sequencing (NGS) techniques has made possible a paradigm shift in cancer treatment, opening the door to the choice of treatment based on a particular biomolecular alteration, rather than the type and location of the tumor, a concept known as tumor-agnostic treatment. 

In this program, the student is trained to recognize the different entities that make up this group of pathologies: uncommon, rare and ultra-rare cancer; orphan tumors; agnostic tumors; and cancer of unknown origin. This postgraduate diploma allows the student to approach precision medicine in the context of uncommon tumors, agnostic treatments and cancer of unknown origin, through the resolution of problems by means of different clinical experiences with precision medicine and will be able to apply genomics in the diagnosis and treatment of this type of tumors. 

Students will be able to complete the program at their own pace, without being subject to fixed schedules or the travel involved in classroom teaching, so they can combine it with the rest of their daily obligations.  

You will know how to apply the knowledge gained to clinical and research problem solving in the area of rare pathology" 

This postgraduate diploma in Orphan, Agnostic Tumors and Tumors of Unknown Origin contains the most complete and up-to-date scientific program on the market. Its most notable features are:

• Case studies presented by experts in oncology
• The graphic, schematic, and practical contents with which they are created, provide scientific and practical information on the disciplines that are essential for professional development
• New developments in the treatment of Orphan, Agnostic Tumors and Tumors of Unknown Origin
• Practical exercises where the self-assessment process can be carried out to improve learning
• Its special emphasis on innovative methodologies in the diagnosis and treatment of Orphan, Agnostic and Tumors of Unknown Origin
• Theoretical lessons, questions to the expert, debate forums on controversial topics, and individual reflection work
• Content that is accessible from any fixed or portable device with an Internet connection

You will develop the judgment necessary to use molecular tools efficiently and safely, which will allow you to detect patients carrying their mutations"     

The teaching staff includes professionals from the Oncology sector, who bring their experience to this educational program, as well as renowned specialists from leading societies and prestigious universities. 

The multimedia content, developed with the latest educational technology, will provide the professional with situated and contextual learning, i.e., a simulated environment that will provide immersive knowledge programmed to learn in real situations. 

This program is designed around Problem-Based Learning, whereby the specialist must try to solve the different professional practice situations that arise throughout the program. For this purpose, the professional will be assisted by an innovative interactive video system created by renowned and experienced experts.

In this TECH program you will delve into the development of numerous agnostic treatments in various pathologies"        

You will learn to use molecular tools in the context of this pathology with success and rigor"

The program in Orphan, Agnostic Tumors and Tumors of Unknown Origin is aimed at facilitating the medical professional's performance with the latest advances and most innovative treatments in the sector. It will allow the student to delve into a field of medicine that needs qualified professionals to carry out the relevant research on these ailments that occur in a small part of the world's population. There, the program has been developed by a team of experts with contents that will enable the future graduate to reach the proposed objectives. For this reason, TECH has established a series of general and specific objectives for the satisfaction of future graduates, as follows.

You will gain in-depth knowledge about biobanks and their role in clinical research, a vital issue in these cases” 

General Objectives

• Acquire concepts and knowledge regarding the epidemiology, clinical, diagnosis and treatment of infrequent tumors, agnostic diagnoses and cancers of unknown origin
• Know how to apply the diagnostic algorithms and evaluate the prognosis of this pathology
• Be able to integrate knowledge and face the complexity of formulating clinical and diagnostic judgments based on the available clinical information
• Know how to apply acquired knowledge and problem-solving skills in new or unfamiliar environments within broader (or multidisciplinary) contexts related to the area of study
• Know how to establish complex therapeutic plans in the context of the pathology in question Have a deeper knowledge of specific treatment networks, reference centers, clinical trials
• Incorporate new technologies into daily practice, knowing their advances, limitations and future potential
• Acquire knowledge about molecular biology tools for the study of these tumors
• Have thorough knowledge and use Tumor Registries
• Know and use the face-to-face or virtual Molecular Committees
• Understand fundamental aspects of biobank operation
• Specialize in interprofessional relationship tools for the treatment of orphan, agnostic and cancer of unknown origin and to access expert networks in the different pathology groups
• Know how to apply knowledge to solve clinical and research problems in the area of rare pathology
• Know how to communicate conclusions, knowledge, and supporting arguments to specialized and non-specialized audiences in a clear and unambiguous way
• Acquire the learning skills to enable further studying in a largely self-directed or autonomous manner
• Possess and understand knowledge that provides a basis or opportunity to be original in the development and/or application of ideas, often in a research context
• Understand the social responsibility due to rare diseases 

Specific Objectives

Module 1. The Reality of Orphan, Agnostic Tumors and Tumors of Unknown Origin

• Be able to place the entities under study in an epidemiological context, to know their incidence and prevalence, as well as the trend of the rates at European level
• Delve into the survival data at European level and the causes of the survival of the differences in survival between rare tumors and reference tumor pathology
• Gain an in-depth understanding of aspects related to precision medicine in the context of rare tumors, agnostic treatments and cancer of unknown origin
• Handle the different models of care for rare tumors, as well as concepts in their field such as tumor registries, expert networks, reference units and tumor board review
• Acquire training on biobanks and their role in clinical research
• Become familiar with the methodological aspects of low incidence tumor research
• Specialize in the European framework of legislation in relation to low incidence tumors, the role of regulatory agencies and the particularities of access to drugs
• Be aware of the implications of all this in the patient's experience, as well as the repercussions of the disease at the psychological and social level

Module 2. Agnostic Tumors

• Become familiar with the concept of agnostic diagnosis
• Delve into the new paradigm in cancer treatment, opening the door to the choice of treatment based on a particular biomolecular alteration, over and above the type and location of the tumor, a concept known as tumor agnostic treatment
• Gain knowledge about one of the most important biomarkers detected is the NTRK fusion gene, which appears in a wide variety of tumor types in both adult and pediatric patients
• Provide the student with the necessary judgment to use molecular tools efficiently and safely to detect patients carrying their mutations
• Manage the approach to tumors with microsatellite instability
• Delve into the development of numerous agnostic treatments in various pathologies

Module 3. Cancers of Unknown Origin

• Delve into the concept of cancer of unknown origin
• Know in depth its modes of presentation and the tests that should be performed in targeted manner
• Acquire the skills for the approach of this disease and the collaboration to optimize the survival of these patients
• Know how use molecular tools in the context of this pathology
• Manage the peculiar aspects of its research approach: basket and umbrella essays

Enter one of the most creative and exciting areas in the world of gastronomy with the background of a complete professional, qualified to successfully lead any project"